翻訳と辞書 Words near each other ・ Staple Hill ・ Staple Hill (Somerset) ・ Staple Hill F.C. ・ Staple Hill railway station ・ Staple Hill, Gloucestershire ・ Staple Inn ・ Staple Island ・ Staple knocker ・ Staple railway station ・ Staple remover ・ Staple right ・ STAPLE! ・ Staple, Kent ・ Staple, Nord ・ Stapled hemorrhoidopexy ・ Stapled peptide ・ Stapled security ・ Stapledon ・ Staplefield ・ Stapleford ・ Stapleford Abbotts ・ Stapleford Aerodrome ・ Stapleford Cross ・ Stapleford Miniature Railway ・ Stapleford Park ・ Stapleford railway station ・ Stapleford Rural District ・ Stapleford Tawney ・ Stapleford Woods ・ Stapleford, Cambridgeshire Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Stapled peptide ： ウィキペディア英語版 Stapled peptide A stapled peptide is a peptide that has a synthetic brace ("staple"). Peptides with multiple, tandem staples are sometimes referred to as stitched peptides. Peptide stapling is used to enhance pharmacologic performance of peptides.〔 ==Introduction== The two primary classes of therapeutics are small molecules and protein therapeutics. It is difficult to design small molecule inhibitors of protein protein interactions and protein therapeutics have poor cell penetration due to insufficient ability to diffuse across the cell membrane. Additionally, protein and peptides are often subject to proteolytic degradation. Furthermore, small peptides (such as single alpha-helices) do not exhibit significant helicity in solution due to entropic factors: this effect diminishes binding affinity.〔 Introducing a synthetic brace (staple) helps to lock a peptide in a specific conformation reducing conformational entropy. This approach can increase target affinity, increase cell penetration, and protect against proteolytic degradation.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Stapled peptide」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.